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Asking ChatGPT a health-related question? Better keep it simple

<p>It’s tempting to <a href="https://cosmosmagazine.com/news/chatgpt-and-dr-google/">turn to search engines</a> to seek out health information, but with the rise of large language models, like ChatGPT, people are becoming more and more likely to depend on AI for answers too.</p> <div class="copy"> <p>Concerningly, an Australian study has now found that the more evidence given to <a href="https://cosmosmagazine.com/technology/chatgpt-an-intimate-companion/">ChatGPT</a> when asked a health-related question, the less reliable it becomes.</p> <p>Large language models (LLM) and artificial intelligence use in health care is still developing, creating a  a critical gap when providing incorrect answers can have serious consequences for people’s health.</p> <p>To address this, scientists from Australia’s national science agency, CSIRO, and the University of Queensland (UQ) explored a hypothetical scenario: an average person asking ChatGPT if ‘X’ treatment has a positive effect on condition ‘Y’.</p> <p>They presented ChatGPT with 100 questions sourced from the <a href="https://trec-health-misinfo.github.io/" target="_blank" rel="noopener">TREC Health Misinformation track</a> – ranging from ‘Can zinc help treat the common cold?’ to ‘Will drinking vinegar dissolve a stuck fish bone?’</p> <p>Because queries to search engines are typically shorter, while prompts to a LLM can be far longer, they posed the questions in 2 different formats: the first as a simple question and the second as a question biased with supporting or contrary evidence.</p> <p>By comparing ChatGPT’s response to the known correct response based on existing medical knowledge, they found that ChatGPT was 80% accurate at giving accurate answers in a question-only format. However, when given an evidence-biased prompt, this accuracy reduced to 63%, which was reduced again to 28% when an “unsure” answer was allowed. </p> <p>“We’re not sure why this happens,” says CSIRO Principal Research Scientist and Associate Professor at UQ, Dr Bevan Koopman, who is co-author of the paper.</p> <p>“But given this occurs whether the evidence given is correct or not, perhaps the evidence adds too much noise, thus lowering accuracy.”</p> <p>Study co-author Guido Zuccon, Director of AI for the Queensland Digital Health Centre at UQ says that major search engines are now integrating LLMs and search technologies in a process called Retrieval Augmented Generation.</p> <p>“We demonstrate that the interaction between the LLM and the search component is still poorly understood, resulting in the generation of inaccurate health information,” says Zuccon.</p> <p>Given the widespread popularity of using LLMs online for answers on people’s health, Koopman adds, we need continued research to inform the public about risks and to help them optimise the accuracy of their answers.</p> <p>“While LLMs have the potential to greatly improve the way people access information, we need more research to understand where they are effective and where they are not.”</p> <p><em>Image credits: Getty Images</em></p> <div> <p align="center"> </p> </div> <p><em><img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=301406&amp;title=Asking+ChatGPT+a+health-related+question%3F+Better+keep+it+simple" width="1" height="1" loading="lazy" aria-label="Syndication Tracker" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /></em><em><a href="https://cosmosmagazine.com/technology/ai/asking-chatgpt-a-health-related-question-better-keep-it-simple/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/imma-perfetto/">Imma Perfetto</a>. </em></div>

Caring

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Why it’s a bad idea to mix alcohol with some medications

<p><em><a href="https://theconversation.com/profiles/nial-wheate-96839">Nial Wheate</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/jasmine-lee-1507733">Jasmine Lee</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/kellie-charles-1309061">Kellie Charles</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>, and <a href="https://theconversation.com/profiles/tina-hinton-329706">Tina Hinton</a>, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p>Anyone who has drunk alcohol will be familiar with how easily it can lower your social inhibitions and let you do things you wouldn’t normally do.</p> <p>But you may not be aware that mixing certain medicines with alcohol can increase the effects and put you at risk.</p> <p>When you mix alcohol with medicines, whether prescription or over-the-counter, the medicines can increase the effects of the alcohol or the alcohol can increase the side-effects of the drug. Sometimes it can also result in all new side-effects.</p> <h2>How alcohol and medicines interact</h2> <p>The chemicals in your brain maintain a delicate balance between excitation and inhibition. Too much excitation can lead to <a href="https://www.medicalnewstoday.com/articles/324330">convulsions</a>. Too much inhibition and you will experience effects like sedation and depression.</p> <p><iframe id="JCh01" class="tc-infographic-datawrapper" style="border: none;" src="https://datawrapper.dwcdn.net/JCh01/1/" width="100%" height="400px" frameborder="0"></iframe></p> <p>Alcohol works by increasing the amount of inhibition in the brain. You might recognise this as a sense of relaxation and a lowering of social inhibitions when you’ve had a couple of alcoholic drinks.</p> <p>With even more alcohol, you will notice you can’t coordinate your muscles as well, you might slur your speech, become dizzy, forget things that have happened, and even fall asleep.</p> <p>Medications can interact with alcohol to <a href="https://awspntest.apa.org/record/2022-33281-033">produce different or increased effects</a>. Alcohol can interfere with the way a medicine works in the body, or it can interfere with the way a medicine is absorbed from the stomach. If your medicine has similar side-effects as being drunk, those <a href="https://www.drugs.com/article/medications-and-alcohol.html#:%7E:text=Additive%20effects%20of%20alcohol%20and,of%20drug%20in%20the%20bloodstream.">effects can be compounded</a>.</p> <p>Not all the side-effects need to be alcohol-like. Mixing alcohol with the ADHD medicine ritalin, for example, can <a href="https://www.healthline.com/health/adhd/ritalin-and-alcohol#side-effects">increase the drug’s effect on the heart</a>, increasing your heart rate and the risk of a heart attack.</p> <p>Combining alcohol with ibuprofen can lead to a higher risk of stomach upsets and stomach bleeds.</p> <p>Alcohol can increase the break-down of certain medicines, such as <a href="https://www.sciencedirect.com/science/article/abs/pii/S0149763421005121?via%3Dihub">opioids, cannabis, seizures, and even ritalin</a>. This can make the medicine less effective. Alcohol can also alter the pathway of how a medicine is broken down, potentially creating toxic chemicals that can cause serious liver complications. This is a particular problem with <a href="https://australianprescriber.tg.org.au/articles/alcohol-and-paracetamol.html">paracetamol</a>.</p> <p>At its worst, the consequences of mixing alcohol and medicines can be fatal. Combining a medicine that acts on the brain with alcohol may make driving a car or operating heavy machinery difficult and lead to a serious accident.</p> <h2>Who is at most risk?</h2> <p>The effects of mixing alcohol and medicine are not the same for everyone. Those most at risk of an interaction are older people, women and people with a smaller body size.</p> <p>Older people do not break down medicines as quickly as younger people, and are often on <a href="https://www.safetyandquality.gov.au/our-work/healthcare-variation/fourth-atlas-2021/medicines-use-older-people/61-polypharmacy-75-years-and-over#:%7E:text=is%20this%20important%3F-,Polypharmacy%20is%20when%20people%20are%20using%20five%20or%20more%20medicines,take%20five%20or%20more%20medicines.">more than one medication</a>.</p> <p>Older people also are more sensitive to the effects of medications acting on the brain and will experience more side-effects, such as dizziness and falls.</p> <p>Women and people with smaller body size tend to have a higher blood alcohol concentration when they consume the same amount of alcohol as someone larger. This is because there is less water in their bodies that can mix with the alcohol.</p> <h2>What drugs can’t you mix with alcohol?</h2> <p>You’ll know if you can’t take alcohol because there will be a prominent warning on the box. Your pharmacist should also counsel you on your medicine when you pick up your script.</p> <p>The most common <a href="https://adf.org.au/insights/prescription-meds-alcohol/">alcohol-interacting prescription medicines</a> are benzodiazepines (for anxiety, insomnia, or seizures), opioids for pain, antidepressants, antipsychotics, and some antibiotics, like metronidazole and tinidazole.</p> <p>It’s not just prescription medicines that shouldn’t be mixed with alcohol. Some over-the-counter medicines that you shouldn’t combine with alcohol include medicines for sleeping, travel sickness, cold and flu, allergy, and pain.</p> <p>Next time you pick up a medicine from your pharmacist or buy one from the local supermarket, check the packaging and ask for advice about whether you can consume alcohol while taking it.</p> <p>If you do want to drink alcohol while being on medication, discuss it with your doctor or pharmacist first.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/223293/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/nial-wheate-96839"><em>Nial Wheate</em></a><em>, Associate Professor of the School of Pharmacy, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/jasmine-lee-1507733">Jasmine Lee</a>, Pharmacist and PhD Candidate, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>; <a href="https://theconversation.com/profiles/kellie-charles-1309061">Kellie Charles</a>, Associate Professor in Pharmacology, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a>, and <a href="https://theconversation.com/profiles/tina-hinton-329706">Tina Hinton</a>, Associate Professor of Pharmacology, <a href="https://theconversation.com/institutions/university-of-sydney-841">University of Sydney</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-its-a-bad-idea-to-mix-alcohol-with-some-medications-223293">original article</a>.</em></p>

Body

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Do psychedelics really work to treat depression and PTSD? Here’s what the evidence says

<p><em><a href="https://theconversation.com/profiles/sam-moreton-194043">Sam Moreton</a>, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p>As of July 1, authorised psychiatrists have been allowed to prescribe MDMA (the chemical found in “ecstasy”) to treat post-traumatic stress disorder (PTSD), and psilocybin (found in “magic mushrooms”) to treat depression that hasn’t responded to other treatment.</p> <p>Psychedelic therapies have researchers excited because evidence suggests they might have lasting beneficial effects on factors that cause psychological distress beyond the treatment period. These include <a href="https://link.springer.com/article/10.1007/s00213-017-4701-y">feeling disconnected from other people</a>, <a href="https://link.springer.com/article/10.1007/s00213-019-05391-0">fear of death</a>, and <a href="https://www.sciencedirect.com/science/article/pii/S2212144719301140?casa_token=OP6tKGxjPHAAAAAA:NTQ4khgsOY5wmsQ5HzCMcZ4eZ43wQV-sdhUbf5LXFiIeKWNwdonhfCxo77k7QbNk4G69EfX-">rigid ways of thinking</a>.</p> <p>This stands in contrast to most medications for psychological issues, which only directly help while people keep taking them regularly.</p> <p>But how strong is the evidence for psychedelic therapy?</p> <h2>Early promise</h2> <p>Early results from studies around the world have found psychedelic therapy <a href="https://www.ranzcp.org/getmedia/0cf57ea2-0bd7-4883-9155-d2ba1958df86/cm-therapeutic-use-of-mdma-for-ptsd-and-psilocybin-for-treatment-resistant-depression.pdf">might be effective</a> for treating a range of psychological issues.</p> <p>For instance, most studies (<a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2032994">but not all</a>) have found patients tend to report <a href="https://pubmed.ncbi.nlm.nih.gov/37357767/">fewer depression symptoms</a> for periods ranging from several weeks to several months after psilocybin therapy.</p> <p>Similarly, studies have found <a href="https://journals.sagepub.com/doi/10.1177/0269881120965915">reductions in PTSD symptoms</a> three weeks after MDMA therapy.</p> <h2>Not so fast</h2> <p>However, as psychedelic research has grown, <a href="https://pubmed.ncbi.nlm.nih.gov/35243919/">limitations</a> of the research have been identified by researchers both <a href="https://psyarxiv.com/ak6gx/">within</a> and <a href="https://www.sciencefictions.org/p/psychedelics">outside</a> the psychedelic field.</p> <p>One issue is that we aren’t sure whether findings might be due to a <a href="https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/placebo-effect">placebo effect</a>, which occurs when a treatment works because people expect it to work.</p> <p>In clinical trials, participants are often given either a medication or a placebo (inactive) drug – and it’s important they don’t know which they have been given. However, due to the strong effects, it is difficult to prevent participants from knowing whether they have been given a psychedelic drug.</p> <p>Researchers have tried to use a range of different drugs (such as Ritalin) as a placebo in order to “trick” those participants not given a psychedelic into thinking they have received one. But this can be difficult to achieve.</p> <p>In 2021, researchers <a href="https://www.tandfonline.com/doi/full/10.1080/17512433.2021.1933434?casa_token=Dovn7x_rkdUAAAAA%3AsPzBTYNTPnNwqj9NvwN0m9ptrP4x4-c83gp3tGcshs30dWHNnmB_Vx-X5H5Y3pZJdG02IWW6X2E">reviewed</a> clinical trials involving psychedelics such as LSD, psilocybin, and dimethyltryptamine (found in animals and plants) for mood and anxiety disorders. They found trials either had not assessed whether participants guessed correctly which drug they had been given, or that this had been tested and participants tended to guess correctly.</p> <p>More recent trials <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2032994">either don’t measure this</a> or find participants have a <a href="https://journals.sagepub.com/doi/full/10.1177/02698811231154852?casa_token=VsPt344fVGwAAAAA%3AA-i1VPBE1EWyFITWNncZEt876lWMiC7rtTOLJBQnb2pHI2775imUJhrzeSZW6r9doaBeDaj61D0">pretty good idea</a> of whether they’ve had a placebo or a psychedelic drug.</p> <p>Given the publicity and excitement around psychedelic research in recent years, it is likely most participants have <a href="https://culanth.org/fieldsights/the-pollan-effect-psychedelic-research-between-world-and-word">strong beliefs</a> such therapies work. This could lead to a significant placebo effect for participants given a psychedelic dose. Additionally, participants who realise they have received a placebo could experience <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184717/">disappointment and frustration</a>, resulting in worse symptoms. The benefits of a psychedelic may seem even greater when they are compared to the experiences of disappointed participants.</p> <h2>Translating trials to practice</h2> <p>Anecdotally, patients might be motivated to report they have gotten better, even when they haven’t.</p> <p>On a 2021 podcast, one clinical trial participant <a href="https://www.psymposia.com/powertrip/">described</a> how, in hindsight, the information they provided to the trial did not accurately capture the worsening of their symptoms. Trial participants are likely aware their results might affect whether treatments are legalised. They may not want to “ruin” the research by admitting the treatment didn’t work for them.</p> <p>There is also uncertainty about whether the findings from clinical trials mean treatments will work in private practice. There may be a lack of clarity around <a href="https://psyarxiv.com/ak6gx/">how trial participants</a> are recruited and selected. Therefore participants may not represent the typical person with PTSD or treatment-resistant depression.</p> <p>And while <a href="https://journals.sagepub.com/doi/full/10.1177/02698811211069100">the safety of psychedelics</a> within controlled contexts is often emphasised by advocates, less is known about safety of psychedelic therapy <a href="https://www.frontiersin.org/articles/10.3389/fpsyt.2021.737738/full">outside</a> clinical trials.</p> <h2>Resolving issues</h2> <p>These issues do not mean the promising psychedelic research conducted over the past several decades is worthless. Nevertheless, a <a href="https://pubmed.ncbi.nlm.nih.gov/35285280/#full-view-affiliation-1">recent review</a> of the effects of MDMA and psilocybin on mental, behavioural or developmental disorders by Australian researchers concluded the “overall certainty of evidence was low or very low”.</p> <p>Dutch researchers recently drafted a <a href="https://psyarxiv.com/ak6gx/">roadmap for psychedelic science</a> with a checklist for future research to help avoid these pitfalls. When more research is done, it might turn out psychedelic treatments help patients and don’t come with unacceptable harms – we simply don’t know that yet.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/208857/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/sam-moreton-194043">Sa<em>m Moreton</em></a><em>, Associate Lecturer, School of Psychology, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/do-psychedelics-really-work-to-treat-depression-and-ptsd-heres-what-the-evidence-says-208857">original article</a>.</em></p>

Mind

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New Maddie McCann theory has "electrified" investigators

<p>An important witness in the Madeleine McCann case has shared a valuable piece of information which has has "electrified" investigators, as the search for the missing child continues. </p> <p>The witness claims that Christian Brueckner, the prime suspect in Maddie's disappearance, had a burglary tool kit that could unlock any security door, and boasted to friends about his lock picking skills. </p> <p>This new theory has raised fresh doubts over the official theory that ­Maddie’s kidnapper clambered in through a window of holiday apartment 5a in Praia da Luz when she was abducted. </p> <p>German police are said to be “electrified” by discovery, and are also probing the possibility that Christian B used car paint solvent to sedate Maddie.</p> <p>In an exclusive interview from a secret location, Helge B – now in German police witness protection – told filmmaker Jutta Rabe for <a href="https://www.thesun.co.uk/news/22893975/madeleine-mccann-suspect-christian-b-lock-pick-kit/"><em>The Sun on Sunday</em>,</a> “He came through the door”.</p> <p>Helge B, 52, who met his fellow German a year before Maddie vanished aged three, said he found the kit at Christian B’s Algarve home.</p> <p>The petty criminal had decided to ransack it with another friend after learning Christian B was serving time for theft.</p> <p>He said, “I knew from Christian that he uses tools to break into holiday resorts, hotels and holiday homes to steal from tourists."</p> <p>“There were passports on the table. There was all sorts of stuff lying around – cameras, suitcases, everything that tourists have with them. I also found a lock pick set.”</p> <p>Helge B, who kept the kit and told German police about it, added, “You can use it to pick any lock, including security locks.”</p> <p>Despite police long believing Maddie's abductor had snuck in through the window, when asked how Christian B might've entered the hotel room, Helge simply said, “Through the door. Easily. He can open any door”.</p> <p>Upon the discovery of the new evidence, a police source said, “The German detectives were electrified by the discovery of the tool kit with the lock picks in it. This evidence is now very important to them."</p> <p>“It confirmed a suspicion that they’d had for a long time – that Christian B entered the apartment through the door.”</p> <p>German prosecutors hope to use the lock picks evidence to nail Christian B, who is in jail for drugs crimes and appealing a seven-year sentence for raping a woman of 72.</p> <p><em>Image credits: Getty Images</em></p>

Legal

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Madonna rushed to intensive care

<p dir="ltr">Madonna was rushed to a hospital in New York and admitted into the ICU on Saturday after being found unresponsive. She has since been treated for a serious bacterial infection.</p> <p dir="ltr">The <em>Material Girl </em>was intubated for at least one night but is now reportedly out of the ICU, alert and recovering, according to Page Six.</p> <p dir="ltr">The singer had her daughter, Lourdes Leon, by her side during the entire ordeal.</p> <p dir="ltr">Madonna’s longtime manager, Guy Oseary, has released a statement on Instagram regarding the incident.</p> <p dir="ltr">“On Saturday June 24, Madonna developed a serious bacterial infection which led to a several day stay in the ICU,” he started the post.</p> <p dir="ltr">“Her health is improving, however she is still under medical care. A full recovery is expected,” he added.</p> <p dir="ltr">Oseary also announced that all of the singer’s current commitments including her upcoming world tour have been “paused” due to the medical emergency, however further details will be provided with new dates for the tour “as soon as we have them”.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/p/CuC6w1TPH_l/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/CuC6w1TPH_l/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Guy Oseary (@guyoseary)</a></p> </div> </blockquote> <p dir="ltr">The “Celebration” tour highlighting her greatest hits and the 40th anniversary of her breakout single, <em>Holiday</em> was set to kick off on July 15 in Vancouver and wrapped up in Amsterdam on December 1.</p> <p dir="ltr">Fans and celebrities alike have sent their love and report for the recovering star in the comment section of Oseary’s post.</p> <p dir="ltr">“Hope she feels better very soon!” commented <em>New Girl</em> actor Zoey Deschanel.</p> <p dir="ltr">“Sending her so much love from us. ❤️❤️❤️” wrote Aussie actress Isla Fisher.</p> <p dir="ltr">“Omg sending her love and healing light! 🙏” commented Ariana Grande’s brother Frankie.</p> <p dir="ltr">“Please send her my love and support. I’ll be sending prayers for her healing ❤️❤️🙏🙏,” wrote one fan.</p> <p dir="ltr">“Health is everything. Take as much time as needed,” commented another.</p> <p dir="ltr"><em>Images: Getty</em></p>

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"A night in hospital and a trip to the burns unit later”: Concerned mum's warning against popular fruit

<p><em><strong>Warning: This article contains images that some readers may find distressing.</strong></em></p> <p>An Aussie mum has taken to the internet and shared photos of her son’s severe burns that came as a result of him playing with a popular fruit. “A night in hospital and a trip to the burns unit later.” She began in her Facebook post.</p> <p>Her son Otis was playing happily outside with a lime in the sunshine, but the next day horror ensued.</p> <p>“It wasn’t until the next day that we noticed a rash appeared.” The mother said.</p> <p>The parents had assumed the rash must’ve been an allergic reaction to the lime juice, however, the rash quickly developed into a “horrific burn,” she added.</p> <p>The parents took Otis to the hospital where they were informed their son was suffering from a condition called phytophotodermatitis.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/p/Cku5QH2thxE/?utm_source=ig_embed&utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Cku5QH2thxE/?utm_source=ig_embed&utm_campaign=loading" target="_blank" rel="noopener">A post shared by Tiny Hearts (@tinyheartseducation)</a></p> </div> </blockquote> <p>Phytophotodermatitis, more commonly known as margarita burn, is a little-known condition which causes burns to the skin when a chemical called furocoumarin reacts to sunlight.</p> <p>The chemical is found in limes, citrus fruit and some plants.</p> <p>“The small lime he had been innocently playing with - had now burnt his skin horrifically!“ The mum said. “If our story can help raise awareness into phytophotodermatitis at least something good has come out of our horrific experience!”</p> <p>The woman has urged parents to be on the lookout for this little-known skin condition.</p> <p>To minimise the risks of phytophotodermatitis, <a href="https://www.healthline.com/" target="_blank" rel="noopener">Healthline</a> suggests washing hands and other exposed parts of the skin immediately after being outdoors, wearing gloves when gardening, putting on sunscreen before going outdoors and wearing long-sleeved tops and pants in wooded areas.</p> <p>Photo credit: Getty</p>

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Benedict Cumberbatch fearing for his life after terrifying home invasion

<p>Benedict Cumberbatch and his family have reportedly been left fearing for their lives as a knife-wielding man broke into the star’s North London home and threatened him.</p> <p>The <em>Daily Mail </em>reported that 35-year-old Jack Bissell, who previously worked as a chef at the Beaumont Hotel in Mayfair, kicked his way through the front gate of the Marvel star’s multimillion-dollar property, allegedly shouting, “I know you’ve moved here. I hope it burns down.”</p> <p>Cumberbatch, 46, his wife, Sophia Hunter, 45, and their three children were reportedly in the home at the time of the break-in and could hear the intruder screaming outside, according to <em>Page Six</em>.</p> <p>Bissell also allegedly took one of the family’s plants and threw it at the garden wall, and ripped the intercom off the building after spitting on it.</p> <p>The intruder reportedly fled the scene before police arrived but, authorities were able to track him down due to DNA evidence he left on the intercom.</p> <p>Bissell was reportedly arrested, fined and slapped with a three-year restraining order from the Cumberbatch family.</p> <p>A source told the outlet, “Naturally all of the family were absolutely terrified and thought this guy was going to get in and hurt them.</p> <p>“Luckily it never went that far. Benedict and Sophie have had many sleepless nights since, worrying that they may be targeted again,” the insider said.</p> <p>“The fact that it was a targeted intrusion makes it a lot more scary.”</p> <p>During the trial, prosecutors said Bissell allegedly told a nearby shopkeeper that he had planned to break into the actor’s home and burn it down.</p> <p>Bissell pleaded guilty and was sentenced on May 10. However, details surrounding the date of the incident have not been disclosed.</p> <p>According to the Daily Mail, facts of the case could not be reported until they “successfully challenged blanket reporting restrictions this week”.</p> <p>No clear connection between Bissell and Cumberbatch has been established.</p> <p><em>Image credit: Getty / Instagram</em></p>

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People with long COVID continue to experience medical gaslighting more than 3 years into the pandemic

<p><em><a href="https://theconversation.com/profiles/simran-purewal-1405366">Simran Purewal</a>, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a>; <a href="https://theconversation.com/profiles/kaylee-byers-766226">Kaylee Byers</a>, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a>; <a href="https://theconversation.com/profiles/kayli-jamieson-1431392">Kayli Jamieson</a>, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a>, and <a href="https://theconversation.com/profiles/neda-zolfaghari-1431577">Neda Zolfaghari</a>, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a></em></p> <p>It’s increasingly clear that the <a href="https://www.worldometers.info/coronavirus/country/canada/">SARS-CoV-2 virus is not going away</a> any time soon. And for some patients, their symptoms haven’t gone away either.</p> <p>In January 2023, our team of researchers at the <a href="https://pipps.ca/">Pacific Institute on Pathogens, Pandemics and Society</a> published a <a href="https://pipps.cdn.prismic.io/pipps/bd160219-3281-4c5d-b8be-57c301e7f99b_Long+Covid+Brief+Feb+2023.pdf">research brief</a> about how people seek out information about long COVID. The brief was based on a scoping review, a type of study that assesses and summarizes available research. Our interdisciplinary team aims to understand the experiences of people with long COVID in order to identify opportunities to support health care and access to information.</p> <h2>Lingering long COVID</h2> <p>Long COVID (also called <a href="https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/symptoms/post-covid-19-condition.html">Post COVID-19 condition</a>) is an illness that occurs after infection with COVID-19, lasting weeks to months, and even years. First coined by a <a href="https://doi.org/10.1016%2Fj.socscimed.2020.113426">patient on Twitter</a>, the term also represents a collective movement of people experiencing the long-term effects of COVID-19 and advocating for care. <a href="https://science.gc.ca/site/science/sites/default/files/attachments/2023/Post-Covid-Condition_Report-2022.pdf">Around 15 per cent</a> of adults who have had COVID still have symptoms after three months or more.</p> <p>Long COVID affects systems <a href="https://doi.org/10.1016/j.socscimed.2021.114619">throughout the body</a>. However, symptom fluctuations and limited diagnostic tools make it challenging for health-care providers to diagnose, especially with <a href="https://doi.org/10.1038/s41579-022-00846-2">over 200 symptoms</a> that may present in patients. Perhaps because long COVID presents itself in many different ways, the illness has <a href="https://doi.org/10.1016/j.socscimed.2021.114619">been contested</a> across the medical field.</p> <p>To identify opportunities to reduce barriers to long COVID care, our team has explored how patients and their caregivers access <a href="https://pipps.cdn.prismic.io/pipps/bd160219-3281-4c5d-b8be-57c301e7f99b_Long+Covid+Brief+Feb+2023.pdf">information about long COVID</a>. We have found that one of the most significant barriers faced by patients is <a href="https://doi.org/10.1177/20552076211059649">medical gaslighting</a> by the people they have turned to for help.</p> <h2>Lack of validation leads to stigma</h2> <p><a href="https://doi.org/10.1136/bmj.o1974">Medical gaslighting</a> occurs when health-care practitioners dismiss or falsely blame patients for their symptoms. While new information about long COVID has become more readily available, some patients continue to face gaslighting and feel that their symptoms are <a href="https://doi.org/10.1016%2Fj.ssmqr.2022.100177">treated less seriously</a> by some health-care professionals.</p> <p>This dismissal can <a href="https://doi.org/10.1111/hex.13602">erode trust</a> in the health-care system and can also lead to <a href="https://doi.org/10.1111/hex.13518">stigma and shame</a>.</p> <p>Preliminary findings from our ongoing study with long COVID patients indicate that, when medical practitioners do not validate a patient’s condition, this extends into community networks of family and friends who may also dismiss their symptoms, contributing to further stigmatization at home.</p> <p>Medical gaslighting can present additional barriers to treatment, such as not being referred to specialists or long COVID clinics. This can, in turn, compound other symptoms such as fatigue, and <a href="https://doi.org/10.1192/bjo.2022.38">exacerbate the psychological symptoms of long COVID</a>, such as depression and anxiety.</p> <p>Medical gaslighting isn’t new. It has been documented by patients with other chronic conditions, such as <a href="https://doi.org/10.5772/intechopen.107936">myalgic encephalomyelitis or chronic fatigue syndrome</a>. And while this is common for patients with <a href="https://doi.org/10.1001/amajethics.2021.512">non-visible illnesses</a>, medical gaslighting is more commonly experienced by <a href="https://doi.org/10.1111/1467-9566.13367">women and racialized people</a>.</p> <p>Long COVID patients also note gender biases, as women with prolonged symptoms feel they are not believed. This is particularly worrisome, as studies have found that <a href="https://doi.org/10.1001/jama.2020.17709">women are disproportionately more likely to experience long COVID</a>.</p> <h2>Where do we go from here?</h2> <p>While long COVID information is constantly shifting, it’s clear that patients face many barriers, the first of which is having their illness minimized or disregarded by others. To ensure that patients have access to compassionate care, we suggest:</p> <p><strong>1. Educating physicians on long COVID</strong></p> <p>Because definitions of long COVID, and its presentation, vary widely, primary care physicians need support to recognize and acknowledge the condition. General practitioners (GPs) must also provide patients with information to help manage their symptoms. This requires actively listening to patients, documenting symptoms and <a href="https://doi.org/10.1136/bmj.m3489">paying close attention to symptoms that need further attention</a>.</p> <p>Training physicians on the full range of symptoms and referring patients to available supports would reduce stigma and assist physicians by reducing their need to gather information themselves.</p> <p><strong>2. Raise awareness about long COVID</strong></p> <p>To increase awareness of long COVID and reduce stigma, public health and community-based organizations must work collaboratively. This may include a public awareness and information campaign about long COVID symptoms, and making support available. Doing so has the potential to foster community support for patients and improve the mental health of patients and their caregivers.</p> <p><strong>3. Ensure information is accessible</strong></p> <p>In many health systems, GPs are <a href="https://doi.org/10.1186/s12913-019-4419-0">gatekeepers to specialists</a> and are considered trusted information sources. However, without established diagnostic guidelines, patients are left to <a href="https://doi.org/10.2196/37984">self-advocate</a> and prove their condition exists.</p> <p>Because of negative encounters with health-care professionals, patients turn to social media platforms, including long COVID <a href="https://doi.org/10.7861%2Fclinmed.2020-0962">online communities</a> on Facebook. While these platforms allow patients to validate experiences and discuss management strategies, patients should not rely only on social media given the <a href="https://doi.org/10.3389/fpubh.2022.937100">potential for misinformation</a>. As a result, it is crucial to ensure information about long COVID is multi-lingual and available in a wide range of formats such as videos, online media and physical printouts.</p> <p>The <a href="https://science.gc.ca/site/science/en/office-chief-science-advisor/initiatives-covid-19/post-covid-19-condition-canada-what-we-know-what-we-dont-know-and-framework-action">recent recommendations of the Chief Science Advisor of Canada</a> to establish diagnostic criteria, care pathways and a research framework for long COVID are a positive development, but we know patients need support now. Improving long COVID education and awareness won’t resolve all of the issues faced by patients, but they’re foundational to compassionate and evidence-based care.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/203744/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/simran-purewal-1405366">Simran Purewal</a>, Research Associate, Health Sciences, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a>; <a href="https://theconversation.com/profiles/kaylee-byers-766226">Kaylee Byers</a>, Regional Deputy Director, BC Node of the Canadian Wildlife Health Cooperative; Senior Scientist, Pacific Institute on Pathogens, Pandemics and Society, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a>; <a href="https://theconversation.com/profiles/kayli-jamieson-1431392">Kayli Jamieson</a>, Master's Student in Communication, Research Assistant for Pacific Institute on Pathogens, Pandemics and Society, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a>, and <a href="https://theconversation.com/profiles/neda-zolfaghari-1431577">Neda Zolfaghari</a>, Project Coordinator, Pacific Institute on Pathogens, Pandemics and Society, and the Pandemics &amp; Borders Project, <a href="https://theconversation.com/institutions/simon-fraser-university-1282">Simon Fraser University</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/people-with-long-covid-continue-to-experience-medical-gaslighting-more-than-3-years-into-the-pandemic-203744">original article</a>.</em></p>

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Many people are tired of grappling with long COVID – here are some evidence-based ways to counter it

<p><a href="https://theconversation.com/profiles/kyle-b-enfield-1409764">Kyle B. Enfield</a>, <em><a href="https://theconversation.com/institutions/university-of-virginia-752">University of Virginia</a></em></p> <p>A patient of mine, once a marathon runner, now gets tired just walking around the block. She developed COVID-19 during the 2020 Christmas holiday and saw me during the summer of 2021. Previously, her primary care doctor had recommended a graded exercise program. But exercise exhausted her. After months of waiting, she finally had an appointment at our post-COVID-19 clinic at the University of Virginia.</p> <p>She is hardly alone in her extended search for answers. Studies suggest that <a href="https://doi.org/10.1016/S0140-6736(22)01214-4">from 10%</a> to <a href="https://doi.org/10.1016/j.eclinm.2022.101762">45% of COVID-19 survivors</a> have at least <a href="https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html">one of the following symptoms three months after recovery</a>: fatigue, cough, shortness of breath, difficulty sleeping, difficulty with daily activities or mental fogginess, otherwise known as “brain fog.”</p> <p>There are many names for this condition: <a href="https://theconversation.com/long-covid-stemmed-from-mild-cases-of-covid-19-in-most-people-according-to-a-new-multicountry-study-195707">long COVID</a>, long-haul COVID, post-acute COVID-19 syndrome and chronic COVID. Patients report that their symptoms, or the severity of them, <a href="http://dx.doi.org/10.1136/bmjgh-2021-007004">fluctuate over time</a>, which <a href="https://theconversation.com/deciphering-the-symptoms-of-long-covid-19-is-slow-and-painstaking-for-both-sufferers-and-their-physicians-164754">makes diagnosis and treatment difficult</a>.</p> <h2>A response to infection</h2> <p>Researchers and doctors have seen <a href="https://doi.org/10.2340/16501977-2694">similar recovery patterns from other viruses</a>, including <a href="https://www.cdc.gov/vhf/ebola/about.html">Ebola</a> and Middle East Respiratory Syndrome, <a href="https://www.lung.org/lung-health-diseases/lung-disease-lookup/middle-eastern-respiratory-syndrome-mers">or MERS</a>, which is another coronavirus.</p> <p>This suggests that the illness we see following a bout with COVID-19 may be part of a patient’s response to the infection. But doctors and researchers do not yet know why some patients go on to have persistent symptoms.</p> <p>My clinical practice and academic research <a href="https://scholar.google.com/scholar?as_ylo=2022&amp;q=Kyle+Enfield&amp;hl=en&amp;as_sdt=0,47">focus on critically ill patients</a>. Most of my patients now are people who had COVID-19 with various levels of severity.</p> <p>I often tell these patients that we are still learning about this disease, which wasn’t part of our vernacular before 2020. Part of what we do at the clinic is help patients understand what they can do at home to start improving.</p> <figure><iframe src="https://www.youtube.com/embed/ype9O4rD3Gk?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe><figcaption><span class="caption">For millions of Americans, COVID-19 is still a part of their lives.</span></figcaption></figure> <h2>Dealing with fatigue</h2> <p><a href="https://doi.org/10.1038/s41598-021-95565-8">Chronic fatigue</a> can greatly affect quality of life. Exercise limitations can have their roots in problems with the lung, heart, brain, muscles or all of the above.</p> <p>Graded exercise therapy works for some but not all patients. Graded exercise is the slow introduction of exercise, starting slowly and gradually increasing in load over time. Many are frustrated because they feel more exhausted after exercising or even doing the routine tasks of daily living. The lack of progress <a href="https://doi.org/10.1016/j.jpsychores.2019.109893">leads to feelings of depression</a>.</p> <p>The condition of feeling more exhausted after exercise <a href="https://www.cdc.gov/me-cfs/healthcare-providers/clinical-care-patients-mecfs/treating-most-disruptive-symptoms.html">is called post-exertional malaise</a>, which is defined as physical and mental exhaustion after an activity, often 24 hours later, that is out of proportion with the activity.</p> <p>For example, you feel good today and decide to go for a walk around the block. Afterward you are fine, but the next day your muscles ache and all you can do is lie on the couch. Some patients don’t even have the energy to answer emails. Rest or sleep do typically relieve the fatigue. There is no one-size-fits-all approach to treatment; the severity and frequency of post-exertional malaise varies from person to person.</p> <h2>Signs and symptoms</h2> <p>Fatigue following any illness is common, as is exercise intolerance. So when should you see a medical professional? Diagnostic testing for post-exertional malaise exists, but it’s not readily available to all patients. These questions may provide clues to whether or not you are experiencing it:</p> <ul> <li>Does it take more than one day to recover to your usual baseline activity?</li> <li>Do you feel unwell, weak, sleep poorly or have pain when recovering from activity?</li> <li>Are you feeling limited in your ability to do your daily tasks after activity?</li> <li>Does exercise activity affect you positively?</li> <li>Do you have soreness and fatigue after nonstrenuous days, or mental fatigue after strenuous or nonstrenuous activities?</li> </ul> <p>All of these can be clues to discuss with your primary care provider, who may want to do additional testing to confirm the diagnosis, such as a <a href="https://me-pedia.org/wiki/Two-day_cardiopulmonary_exercise_test">two-day cardiopulmonary exercise test</a>.</p> <p>Before your appointment, there are a few things you can do at home that may help.</p> <h2>Taking it easy</h2> <p>One of those techniques is pacing, or activity management, an approach that balances activities with rest.</p> <p>The <a href="https://www.rcot.co.uk/">Royal College of Occupational Therapists</a> and the <a href="https://ics.ac.uk/">Intensive Care Society</a>, both in the U.K., developed what they call the <a href="https://www.rcot.co.uk/conserving-energy">3Ps – Pace, Plan and Prioritize</a>.</p> <p>Pacing yourself means breaking down activities into smaller stretches with frequent breaks rather than doing it all at once. An example would be to climb a few steps and then rest for 30 seconds, instead of climbing all the stairs at once.</p> <p>Planning involves looking at the week’s activities to see how they can be spread out. Think about the ones that are particularly strenuous, and give yourself extra time to complete them.</p> <p>This helps with prioritizing – and recognizing those tasks that can be skipped or put off.</p> <h2>Focusing on the breathing</h2> <p>Some patients with long COVID develop abnormal breathing patterns, including shallow rapid breathing, known as hyperventilating, or breath-holding. Either of these patterns can make you feel short of breath.</p> <p>Symptoms of abnormal breathing patterns include frequent yawning, throat-clearing, experiencing pins-and-needles sensations, palpitations and chest pain. Don’t ignore these symptoms, because they can be signs of serious medical problems like <a href="https://www.cdc.gov/heartdisease/heart_attack.htm">heart attacks</a> and <a href="https://www.cdc.gov/heartdisease/atrial_fibrillation.htm">abnormal heart rhythms</a>. Once those are ruled out, it is possible to relearn to breathe properly.</p> <p>You can <a href="https://longcovid.physio/breathing-pattern-disorders">practice these techniques at home</a>. The simple version: Find a comfortable position – either lying down or sitting upright with your back supported. Place one hand on your chest and the other over your belly button. Exhale any stale air out of your lungs. Then breathe in through your nose and into your abdomen, creating a gentle rise in the belly.</p> <p>You should feel the hand resting on your belly button move up and down. Try to avoid short, shallow breaths into the upper chest. Slowly exhale all the air out of your lungs. The goal is to take around eight to 12 breaths per minute.</p> <p>Focus on a longer exhale than inhale. For example, inhale as described for a count of two, then exhale for a count of three, as a starting point. If you take one breath every five seconds, you will be breathing 12 breaths per minute. As you get more comfortable with this, you can increase the time to further reduce your breaths per minute.</p> <figure><iframe src="https://www.youtube.com/embed/tEmt1Znux58?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe><figcaption><span class="caption">Box breathing is easy to learn and you can do it anywhere, anytime.</span></figcaption></figure> <p>A more advanced tool <a href="https://www.youtube.com/watch?v=a7uQXDkxEtM">is called box breathing</a>: Breathe in for a count of four to five, holding your breath for a count of four to five, breathing out for a count of four to five and hold that for a count of four to five.</p> <p>Long COVID patients who use these techniques show improvement in <a href="https://doi.org/10.1016/S2213-2600(22)00125-4">symptoms of breathlessness and sense of well-being</a>.</p> <h2>The road to recovery</h2> <p>The patient I referred to earlier did all of these things. As we worked with her, we discovered she had multiple reasons for her symptoms. In addition to overbreathing and symptoms of post-exertion malaise, she had a new cardiac problem, possibly related to her COVID-19 illness, that made her <a href="https://doi.org/10.1161/JAHA.121.024207">heart work less well during exercise</a>. Now she is recovering; while not back to marathon running, she is feeling better.</p> <p>Currently there is no cure for long COVID, though we hope research will lead to one. <a href="https://clinicaltrials.gov/ct2/results?cond=long+covid&amp;term=&amp;cntry=&amp;state=&amp;city=&amp;dist=">Clinical trials looking at potential therapies</a> are continuing. In the meantime, people should be cautious about using medications that are not proved to help – and if you’re having symptoms, get evaluated.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/201451/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/kyle-b-enfield-1409764">Kyle B. Enfield</a>, Associate Professor of Medicine, <a href="https://theconversation.com/institutions/university-of-virginia-752">University of Virginia</a></em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/many-people-are-tired-of-grappling-with-long-covid-here-are-some-evidence-based-ways-to-counter-it-201451">original article</a>.</em></p> <p><em>Images: Getty</em></p>

Body

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9 medical reasons your short-term memory is getting worse

<p><strong>What is short-term memory?</strong></p> <p>Short-term memory is the type of memory you need to accomplish your immediate goals, explains Dr Patrick Lyden, chair of the department of neurology at Cedars-Sinai Hospital. That may be working your way through tasks during the workday, remembering someone’s name, email, or phone number, or recalling where you tossed your keys when you got home.</p> <p><strong>Where is it located in the brain?</strong></p> <p>When someone rattles off their phone number, you file it away in brain circuits that include the hippocampus (your memory centre) and the amygdala (your emotional hub). Depending on how important the short-term memory item may be (your address, someone you call all the time), it can be converted into long-term memory, says Dr Lyden.</p> <p><strong>How does short-term memory work?</strong></p> <p>Short-term memory isn’t just about being able to quickly recall new info; there are three phases. “You have to register the information, store the information, and retrieve the information,” says Dr Lyden. Registering means that you’re paying attention in the first place. Storing the info means you’ve filed it away in your brain. Retrieval is the ability to access the memory again. Any of these steps can break down, he says.</p> <p><strong>Is your memory okay?</strong></p> <p>Many people assume they have a memory problem when the explanation is something else entirely, says Dr Lyden. Maybe you’re not paying attention because you’re gazing at your phone or texting, for example. The first step to figuring out if something is going on is to “pay closer attention,” he says. Repeat the new information three times to commit it to memory.</p> <p><strong>When it may be time to worry</strong></p> <p>If you can’t pass the “pay attention test” despite repeating the information, your next step, advises Dr Lyden, is to determine if your problem is storing new memories or retrieving them. If you’re having a problem remembering a new acquaintance’s name, ask them to give you three choices – like Carrie, Lauren, or Janet. If your problem is storing new memories, you won’t be able to remember. But if your problem is retrieval, you’ll remember that her name is Janet once you hear the correct name.</p> <p>Having trouble with retrieving a short-term memory isn’t as serious as being unable to store them. “The storage problem is a serious problem, and you should see a neurologist,” he says.</p> <p><strong>Inactivity</strong></p> <p>Blood flow is good for your brain – it keeps it young. “Exercising boosts blood flow to your brain. If you stay active, you’ll have a better memory,” says Dr Daniel G. Amen, author of <em>Memory Rescue: Supercharge Your Brain, Reverse Memory Loss, and Remember What Matters Most</em>. Dr Lyden suggests daily exercise and it doesn’t have to be intense. “A one-kilometre run daily is better than a 10-kilometre run one day a week,” he says.</p> <p><strong>Substance abuse</strong></p> <p>According to Dr Amen, marijuana a toxin that impairs memory. “Marijuana lowers every area of the brain and ages it. On average, pot smokers have brains three years older than non-smokers,” he says. Alcohol abuse can also harm your memory.</p> <p><strong>Mental health conditions</strong></p> <p>People tend to miss their own depression. But if you’re suffering from depression, anxiety, or chronic stress, get help or your memory can also pay the price. “These conditions may all hurt the brain,” says Dr Amen. Getting relief will not only improve your life and outlook but save your brain.</p> <p><strong>Lack of sleep</strong></p> <p>When considering short-term memory loss causes, poor sleep is a big one. “If you don’t sleep seven hours a night or more, you’ll be in trouble. Your brain cleans itself at night. When you don’t get enough, it’s like the garbage collectors didn’t come to clean up,” says Dr Amen.</p> <p><strong>Dementia</strong></p> <p>Before you panic, there’s some good news: “The vast majority of people who are healthy will not have a degenerative neurological condition causing short-term memory loss,” says Dr Lyden. But dementia or Alzheimer’s is a possibility in some groups. If you’re over 60 and have risk factors like diabetes, high blood pressure, or obesity, then you may be more prone to problems and need to be evaluated, he says.</p> <p><strong>Medication</strong></p> <p>If you lead a healthy lifestyle, eat right, exercise, and go easy on alcohol and other substances that can harm memory, yet you still feel like your memory if failing, talk to your doctor about your medications – prescription and over-the-counter, advises Dr Lyden. Cholesterol drugs, painkillers, high blood pressure pills, and sleeping pills are among the drugs that can trigger memory issues.</p> <p><strong>Hypothyroidism</strong></p> <p>When you have an under-active thyroid, everything in your body runs slower. Your digestion will slow and you can become constipated; cell growth slows and can lead to hair loss; your metabolism becomes sluggish, triggering weight gain. And you may be plagued by muddied thinking or forgetfulness. Often, medication to restore thyroid hormones can help alleviate symptoms and help you feel better all over.</p> <p><strong>A poor diet</strong></p> <p>Inflammation is bad for your body and your brain. “The higher the inflammation levels in your body, the worse your memory will be,” says Dr Amen. Eating an anti-inflammatory diet, like the Mediterranean diet, and avoiding foods that increase it (highly processed foods, loads of sugar) is key. He also recommends taking fish oil and probiotics.</p> <p><strong>Lyme disease</strong></p> <p>Lyme disease is transmitted through a tick bite, and causes early symptoms like fever, chills, headache, and fatigue, according to the Centers for Disease Control and Prevention (CDC). Later on, without treatment, some people also may notice short-term memory problems. Dr Amen points out this may include trouble with attention, focus, and organisation. Keep in mind that the types of tick that carry the bacteria are not native to Australia and it’s not likely you can catch Lyme disease in Australia.</p> <p><strong>When to seek help</strong></p> <p>Along with the self-test mentioned earlier, think about how you perceive your short-term memory. Ask yourself: Is it getting progressively worse? Is it worse than 10 years ago? Are other people noticing a problem? “Those are things you should take seriously,” says Dr Amen.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://www.readersdigest.co.nz/healthsmart/9-medical-reasons-your-short-term-memory-is-getting-worse-2?pages=1" target="_blank" rel="noopener">Reader's Digest</a>. </em></p>

Mind

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Know the signs of a heart attack this Heart Week

<p dir="ltr">Research conducted by Heart Smart Australia, an online health and wellbeing program, has revealed the concerning reality that only one third of Australians (38% of the 1,031 people surveyed) are able to recognise the symptoms of a heart attack, despite cardiovascular disease being attributed to <a href="https://www.heartfoundation.org.au/bundles/for-professionals/key-stats-cardiovascular-disease">25% of deaths in the country</a>. </p> <p dir="ltr">And during <a href="https://campaign.heartfoundation.org.au/heart-week">Heart Week</a>, which runs from May 1 to May 7, the organisation hopes to both raise awareness and educate everyone on the warning signs, from the obvious to the lesser known, to hopefully reduce an individual’s risk of heart disease.</p> <p dir="ltr">As explained on the official website for the initiative, Heart Week is “Australia’s national heart health awareness week” and “provides an opportunity for the Australian public and health professionals to start a conversation about heart health and take positive steps to reduce their heart disease risk.” </p> <p dir="ltr">Surprisingly, the generation with the least existing awareness are the Baby Boomers, with research showing that only 33% of them are typically able to recall all of the signs and symptoms.</p> <p dir="ltr">Roughly 98% of Australians were able to call one or more of the most common symptoms to mind, while only 55% were aware that fatigue is one of such signs. Fewer still - approximately 48% - could name nausea and vomiting as another. </p> <p dir="ltr">The numbers are far lower than ideal, and as leading cardiologist and Chief Medical Officer of Heart Smart Australia Dr Ross Walker explained, “heart attack can be a silent killer; therefore, it’s crucial that Australians are aware of all the symptoms, including the lesser-known ones such as fatigue, chest discomfort and vomiting.</p> <p dir="ltr">“If you experience any of these symptoms, it's important to seek medical attention immediately. We know that acting quickly reduces damage to the heart and increases chances of survival - it really is this important. Life or death!"</p> <p dir="ltr">Cardiovascular disease (otherwise known as CVD) accounts for a staggering one hospitalisation every single minute in Australia, so this Heart Week, Dr Walker is calling on everyone to get on top of their health, to learn the symptoms, and to make the necessary changes towards reducing the impact and risk of CVD. </p> <p dir="ltr">“Heart Health Week is the perfect opportunity for Australians to take stock of their heart health and make positive changes to their lifestyle,” he explained. “For example, we know that implementing some simple changes can reduce the risk profile for developing CVD. </p> <p dir="ltr">“Looking at things like participating in regular exercise, maintaining a healthy weight, not smoking, getting adequate sleep and eating a healthy, balanced diet are key."</p> <p dir="ltr">Some of Dr Walker’s main tips include forming strong social networks, not overlooking the importance of a healthy diet, exercising regularly, attending regular heart health check ups with medical professionals, and knowing the symptoms. </p> <p dir="ltr">“It’s not widely known, nor understood, but those with strong ties to friends and family fare better when it comes to lowering risk of heart disease. Regularly spend some guilt free time with loved ones - it’s for your heart,” he said. </p> <p dir="ltr">And as for diet, “Variety is key here. As well as a range of fruit and vegetables, including things like Omega 3’s and turmeric can work to decrease inflammation, a key risk factor for CVD.”</p> <p dir="ltr">For exercise, Dr Walker recommends a minimum of “5 or more active days”, with no less than two-and-a-half hours each week dedicated to physical activity.</p> <p dir="ltr">Heart health check ups are crucial, according to Dr Walker, who suggests that anyone over the age of 45 (or 30 for Indigenous Australians) should contact their doctor for a check up. </p> <p dir="ltr">“This check will include things like measuring blood pressure, cholesterol levels and assessing weight,” he noted. “Identifying risk works to pre-empt issues and is often an important preventative measure.” </p> <p dir="ltr">And when it comes to the symptoms, Dr Walker believes it to be imperative to recognise them, so that you can act immediately and get help as soon as possible if someone you know may be suffering from one, “as early treatment is strongly linked to better health outcomes”.</p> <p dir="ltr">Those all-important symptoms include chest pains - pressure and tightness - as well as dizziness and light-headedness, nausea or vomiting, indigestion, sweat, an unusually pale complexion, difficulty breathing and shortness of breath, and palpitations. </p> <p dir="ltr">Additionally, when dealing with a suspected heart attack in females, it’s important to watch out for breathlessness and general unwellness, tightness and discomfort of the arms, chest pains that are reminiscent of burning and trapped wind, as well as upper back pain and pressure in the area. </p> <p dir="ltr">For more information, and to learn more about the education and support on offer, head over to Heart Smart Australia’s official website: <a href="https://heartsmartaustralia.com/">https://heartsmartaustralia.com/</a> </p> <p dir="ltr"><em>Images: Getty</em></p>

Body

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“Game-changer”: Michael J Fox shares huge medical news

<p dir="ltr">Michael J Fox has shared news of a medical breakthrough into Parkinson’s disease.</p> <p dir="ltr">The 61-year-old – who was diagnosed with the disease in 1991 – was thrilled to share the news, despite suffering a “terrible year”.</p> <p dir="ltr">Fox told <a href="https://www.statnews.com/2023/04/12/michael-j-fox-parkinsons-biomarker/" target="_blank" rel="noopener"><em>Stat News</em></a> that he had broken multiple bones after a fall, including some in his hand and face, but has said that in some ways he is “feeling better”.</p> <p dir="ltr">Despite his own personal battle, the <em>Back to the Future</em> star was overjoyed to share the breakthrough in Parkinson’s research.</p> <p dir="ltr">The study – funded by Fox’s charity organisation that aims to find a cure for Parkinson’s – found that a key Parkinson's pathology can now be identified by examining spinal fluid from living patients, allowing earlier intervention.</p> <p dir="ltr">“It’s all changed. It can be known and treated early on. It’s huge,” he said</p> <p dir="ltr">“This is the thing. This is the big reward. This is the big trophy.”</p> <p dir="ltr">The findings, published in <em>The Lancet Neurology</em>, are the result of a 1,123-person study that Fox’s foundation has put hundreds of millions of dollars into since it began in 2010.</p> <p dir="ltr">An editorial in the medical journal has also called this research “a game-changer in Parkinson’s disease diagnostics, research, and treatment trials”.</p> <p dir="ltr">In late 2022 the actor opened up about his struggle with Parkinson’s in his emotional acceptance speech for the <a href="https://www.oversixty.co.nz/health/caring/michael-j-fox-reveals-more-details-about-his-struggle-with-parkinson-s" target="_blank" rel="noopener">Jean Hershel Humanitarian Award</a>.</p> <p dir="ltr">In the speech he said that the hardest part “was grappling with the certainty of the diagnosis and the uncertainty of the situation,” but has since felt relieved after an “outpouring of support” from the public and his peers.</p> <p><em>Image: Frazer Harrison for Getty Images</em></p>

Caring

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Mum of four saved by her smartwatch

<p dir="ltr">Ricki-Lee Wynne was gifted a smartwatch from her husband for her 40th birthday and she believes that without it, she wouldn’t be alive today.</p> <p dir="ltr">"There's no doubt that my smartwatch saved my life," she told 9news.com.au.</p> <p dir="ltr">Months prior to receiving the watch, Wynne had been experiencing strange health problems. </p> <p dir="ltr">"I was getting a pain over my shoulder blades and it hurt each time I breathed in," she said.</p> <p dir="ltr">Doctors were confused and Wynne was in and out of hospital having several X-rays, scans and blood tests in an attempt to find the underlying issue.</p> <p dir="ltr">Wynne also had an echocardiogram to test the functioning of her heart, all of which appeared normal. </p> <p dir="ltr">"The doctors were not sure what it was. They thought it could be a low-grade blood cancer," she said. </p> <p dir="ltr">The pain subsided for a little while but soon enough Wynne’s breathing problems returned. </p> <p dir="ltr">"I woke up one day and I couldn't breathe properly. I was just walking into work and I was thinking, 'Gosh, I can't get enough air into my lungs,'" she said.</p> <p dir="ltr">"I couldn't walk from one side of the room to the other without being short of breath.</p> <p dir="ltr">"I went to my GP and had an x-ray done, but nothing showed up.”</p> <p dir="ltr">That’s when Wynne noticed her smartwatch was acting up. </p> <p dir="ltr">"I'd been struggling with my watch for days to try and get the heart rate to show up," she said. </p> <p dir="ltr">The heart rate function of her smartwatch had never been an issue before, but now it was struggling to pick it up. </p> <p dir="ltr">"It was saying you need to change the position to measure a pulse," she said.</p> <p dir="ltr">"My chest was also feeling kind of wobbly for a couple of nights when I went to bed.”</p> <p dir="ltr">Despite her X-ray showing coming up clear, Wynne said she went back to see her GP and told him she was worried something was really wrong.</p> <p dir="ltr">"I just said to him, 'Even my heart rate isn't right, look at my watch,' and I showed it to him.”</p> <p dir="ltr">Wynne’s GP sent her off for an ECG which showed her heart rate had dropped to just 29 beats per minute, a major cause for concern. </p> <p dir="ltr">"As soon as I had the ECG, I had the doctor call me back and say you need to go straight to Box Hill Hospital," she said.</p> <p dir="ltr">"I was told at the hospital that if I hadn't come in I would have just died in my sleep.</p> <p dir="ltr">"I would not have woken up and my heart would have stopped.”</p> <p dir="ltr">Wynne was then fitted with an emergency pacemaker and eventually diagnosed with a rare auto-immune disorder called sarcoidosis, a condition that causes inflammation in different parts of the body, most commonly the lungs. </p> <p dir="ltr">Doctors believe Wynne's sarcoidosis moved from her lungs to her heart, causing her to become extremely ill. </p> <p dir="ltr">She still has the pacemaker in and combined with medication, her health has improved significantly. </p> <p dir="ltr">It’s safe to say Wynne won’t be taking off her smartwatch any time soon.</p> <p dir="ltr"><em>Image credit: Shutterstock</em></p>

Technology

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F1 legend shares rare update Michael Schumacher

<p>Formula 1 icon Eddie Jordan has shared a health update about his close friend Michael Schumacher, saying the motorsport legend is “there, but not there” as mystery continues to surround his health.</p> <p>Schumacher, 54, has not been seen or heard from for nearly ten years after his horror ski crash in 2013.</p> <p>He was left with a severe brain injury and in a medically induced coma.</p> <p>Mystery surrounds his condition as his family has imposed a strict “family only” rule on who can visit him.</p> <p>It came as Michael’s son Mick followed in his dad’s footsteps into F1.</p> <p>Unfortunately, 23-year-old Mick struggled and lost his race seat at the end of 2022 after a series of crashes for the Haas team.</p> <p>Eddie was denied a visit to see Michael but has been in contact with Mick.</p> <p>The F1 star said his “love” for the seven-time world champion “still lasts and will always do so while I’m able to draw breath.” when speaking to sports betting firm OLBG.</p> <p>Last year, he revealed his son Mick had reached out to him.</p> <p>“As far as I’m concerned, I was touched by it and the reason I was touched by it was because it can’t be easy knowing that your father is not able to be part of the family, he’s there but he’s not there,” Jordan said.</p> <p>Jordan revealed that Mick spoke highly of his father while he was enduring his own struggles in F1.</p> <p>“It touched me because I felt so much about Michael, I went out of my way to find him, give him his first chance in Spa, didn’t last very long but that love for him still lasts and will always do so while I’m able to draw breaths,” Eddie said.</p> <p>Mick was dropped by Haas in favour of veteran driver Nico Hulkenberg for 2023 and is now a reserve driver at Mercedes.</p> <p>Mick will be backing up Sir Lewis Hamilton and George Russell, potentially stepping in for them if they have to miss a race.</p> <p>Eddie believes Mick has it in him to find his way back into a full-time race seat.</p> <p>“He’s been dropped for somebody else, and that’s a tough decision, he has another fight to come back and to make his name, climb up that ladder again,” Eddie said.</p> <p>“I’m quite sure he will do it.”</p> <p>Jordan also revealed Michael named his son after racing champion Mick Doohan, saying Mick was given his name “as a mark of respect” to Doohan.</p> <p>“Mick Schumacher isn’t named after his dad like a lot of people seem to think,” he said.</p> <p>“Mick Schumacher is named after a person who his father, Michael, was in total awe of, a sportsman who had won five world titles back to back with Honda.</p> <p>“And that is no other than Mick Doohan.</p> <p>“As a mark of respect, Michael Schumacher called his son Mick.”</p> <p>Last year, Jordan revealed that Michael’s wife denied him permission to visit Schumacher after his horror skiing accident.</p> <p>His wife Corinna keeps his health journey a closely guarded secret.</p> <p>Corinna prefers to treat her husband privately at their home in Geneva, Switzerland, with ex-Ferrarri boss Jean Todt, one of the only people allowed to see him outside his immediate family.</p> <p>Jordan said he contacted Corinna, who was once the girlfriend of his team’s driver Heinz Harold Frentzen.</p> <p>Jordan told the Irish Daily Mirror, “I reached out and one stage asked was it appropriate and did I think we should go and visit him.</p> <p>“The answer was no. No visitations for anyone at that moment except the actual direct family.</p> <p>“However, since then, young Mick Schumacher – Michael’s son – has reached out to me, and he has been extraordinary.”</p> <p><em>Image credit: Getty</em></p>

Caring

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Woman shares "evidence" that she is Madeleine McCann

<p>A young woman from Poland has shared "evidence" to support her claims that she is Madeleine McCann. </p> <p>Julia Wendell went viral after starting an Instagram account named @iammadeleinemcann, which claims she began wondering if she was Maddie “a few months ago” after hearing “something” suspicious from her grandma.</p> <p>Julia has since amassed an online following of almost 500,000 people who are gripped by the latest twist in one of the world’s most infamous unsolved cases. </p> <p>The 21-year-old went on to share a series of photographs which she believes prove her likeness to the missing girl. </p> <p>In one video, Julia showed marks on her body that are similar to Maddie’s, while also showing their similar facial structure. </p> <p>Perhaps the most convincing image is one showing Julia with what appears to be a similar eye defect to the one missing Madeleine also has.</p> <p>In Maddie’s case, this was caused by an extremely rare condition in her right eye, which police had hoped for years would help identify her.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/p/Cou2m5Dt7vs/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Cou2m5Dt7vs/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Help me, I need to talk with Kate and Gerry McCann (@iammadeleinemccan)</a></p> </div> </blockquote> <p>Julia told followers she’s not looking for viral fame and “truly believes” she is missing Maddie, even asking her parents for proof of her birth and contacting police. </p> <p>“Police investigators from UK and Poland try to ignore me. I will tell my story in posts here. Help me,” she wrote on Instagram.</p> <p>Julia has called on Maddie's parents, Kate and Gerry McCann, to agree to a DNA test to prove Julia is who she says she is. </p> <p>Her story has caught the attention of the McCann's, with a source telling the <a href="https://www.dailystar.co.uk/news/girl-who-says-shes-maddie-29250933" target="_blank" rel="noopener"><em>Daily Star</em></a>, “The family are taking no chances, they are willing to look at all leads.”</p> <p>“It is important they look at all of the factors, the girl does look similar. There’s no disputing that.</p> <p>“If what she says is true, there is every chance it could be her. It all adds up.”</p> <p>Kate and Gerry, now both 54, recently pledged to “never give up” their quest to find their missing daughter – adding they were entering their 16th year without her with “continued determination and positivity”.</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/p/Cov49H9o37g/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/p/Cov49H9o37g/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Help me, I need to talk with Kate and Gerry McCann (@iammadeleinemccan)</a></p> </div> </blockquote> <p>Madeleine McCann, from Leicestershire in the UK, went missing from her bed in a holiday apartment in the Portuguese resort town Praia da Luz on the evening of May 3rd 2007.</p> <p>She was three years old at the time of her disappearance, meaning if she was alive today, she would be 19. </p> <p>Despite Julia's beliefs, and her online following supporting her claims, investigators in Germany believe Madeleine was killed by Christian Brueckner. </p> <p>He was charged with three counts of aggravated rape and two counts of sexual abuse of children in October last year. </p> <p>The alleged offences span a 17-year period between 2000 and 2017, <a title="www.thesun.co.uk" href="https://www.thesun.co.uk/news/20073185/madeleine-mccann-suspect-charged-germany-2/" target="_blank" rel="noopener"><em>The Sun</em></a><em> </em>reported at the time.</p> <p>Brueckner has never been charged with any offence related to Maddie's disappearance, and despite extensive police efforts, Madeleine's body has never been found. </p> <p><em>Image credits: Instagram </em></p>

News

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Love languages are hugely popular – but there’s very little evidence they exist at all

<p>Love languages – the concept coined by Baptist pastor Gary Chapman some 30 years ago – has taken the relationships world by storm. It’s often the “go-to” topic on first dates, and for those in relationships love languages are said to provide deep, meaningful and reliable insights into how relationships function. Putting love languages into action is believed to increase relationship happiness.</p> <p>The concept clearly has appeal. At last count, 20 million copies have been sold worldwide of Chapman’s 1992 book The Five Love Languages: The Secret to Love that Lasts. The book has been translated into 49 languages.</p> <p>There is only one catch. There is little evidence to support the idea that love languages are “a thing”, or that love languages do much of anything to help improve relationships.</p> <h2>What are the love languages?</h2> <p>According to <a href="https://books.google.com.au/books?hl=en&amp;lr=&amp;id=j6d2EAAAQBAJ&amp;oi=fnd&amp;pg=PT9&amp;dq=chapman+(1992)+the+five+love+languages&amp;ots=nDeGjK61-3&amp;sig=cBkMcFvfus9SdjVo7_XMWwCSQdo#v=onepage&amp;q=chapman%20(1992)%20the%20five%20love%20languages&amp;f=false">Chapman</a>, there are five love languages. Each of these love languages is a way to communicate your love to your romantic partner.</p> <p>In his role as a Baptist pastor, Chapman had been counselling couples for years. It was through his observations of couples that the idea of love languages was born. </p> <p>He believed love languages were an intuitive and simple way to teach couples about how to tune into each other’s ways of expressing love. And so, he began running seminars for husbands and wives, and the popularity of his seminars grew. </p> <p>The five love languages are: </p> <p>(1) acts of service (doing something that helps a partner, such as running an errand)</p> <p>(2) physical touch (demonstrating physical affection, such as giving your partner a hug or kiss)</p> <p>(3) quality time (spending time together and giving each other undivided attention)</p> <p>(4) gifts (giving your partner a present that communicates thoughtfulness, effort, and/or expense)</p> <p>(5) words of affirmation (such as expressing your admiration, or complimenting your partner). </p> <p>Chapman suggests that people typically use all love languages, but that most people tend to rely on one love language most of the time. This is referred to as a person’s primary love language. </p> <p>According to Chapman, people are more satisfied in their relationships when both partners match when it comes to their primary love language. However, people experience less satisfaction in their relationships when both partners do not share the same primary love language. </p> <p>Another important aspect of the love languages concept is that relationships are likely to deliver the greatest satisfaction when a person can understand their partner’s love language, and act in ways that “speaks to” their partner’s language. In essence, this idea is about tuning in to what a partner wants. </p> <p>This is an idea that has existed across many models and theories about how relationships function well. That is, responding to a partner in a way that meets their needs and wants makes a person feel <a href="https://www.sciencedirect.com/science/article/pii/S2352250X16300884">understood, validated, and cared for</a>.</p> <h2>What does the evidence tell us?</h2> <p>Despite the popularity of the theory of love languages, only a handful of studies have been conducted and reported over the past 30 years. Research is largely inconclusive, although the balance sways more towards refuting rather than endorsing the love languages concept.</p> <p>Let’s start with how love languages are assessed. In popular culture, the <a href="https://5lovelanguages.com/">Love Language QuizTM</a> is an online questionnaire that people can complete to find out about their love languages. Despite millions of individuals having taken the quiz (according to 5lovelanguages.com), there are no published findings as to the reliability and validity of the measure. </p> <p><a href="https://www.tandfonline.com/doi/abs/10.1080/17464090500535822">Researchers</a> have developed their own version of the love languages survey, but the findings did not meet the statistical thresholds to suggest the survey adequately captured the five love languages. Also, their findings did not support the idea that there are five love languages.</p> <p>Furthermore, a qualitative study in which <a href="https://www.tandfonline.com/doi/full/10.1080/08934215.2022.2113549?src=recsys">researchers</a> coded the written responses of undergraduate students to questions about how they express love, suggested there may be six love languages. However, the researchers reported difficulty agreeing on how some of the students’ responses neatly fitted into Chapman’s love languages, particularly in the categories of “words of affirmation” and “quality time”. </p> <p>Next, let’s turn to research testing a core premise of the love language theory: that couples with matching love languages experience greater satisfaction than those who do not. Evidence for this premise is very mixed.</p> <p>Three <a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/pere.12182">studies</a>, including <a href="https://psycnet.apa.org/record/2018-53018-004">one</a> that used Chapman’s Love Language Quiz, have found that couples with matching love languages were no more satisfied than couples who were mismatched. </p> <p>However, a more recent <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0269429#sec006">study</a> found that partners with matching love languages experienced greater relationship and sexual satisfaction than partners with mismatched love languages. This research also found that men who reported greater empathy and perspective-taking had a love language that better matched the language of their partner.</p> <p>Finally, what does the research say about whether having a better understanding of your partner’s love language is linked to higher relationship satisfaction? Only <a href="https://www.proquest.com/openview/33e5ad9d94f22e2e3ed60d20094eec27/1?pq-origsite=gscholar&amp;cbl=18750&amp;diss=y">two</a> studies have investigated this question. Both <a href="https://www.proquest.com/openview/0e7114482de1edf3625039e63b72e678/1?pq-origsite=gscholar&amp;cbl=18750&amp;diss=y">found</a> that knowing your partner’s primary love language did predict relationship satisfaction in the present or into the future.</p> <p>So, as you can see, not only is there very little research investigating love languages, but the research to date doesn’t strengthen belief in the powerful properties of love languages.</p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/love-languages-are-hugely-popular-but-theres-very-little-evidence-they-exist-at-all-198065" target="_blank" rel="noopener">The Conversation</a>. </em></p>

Relationships

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Are our phones really designed to slow down over time? Experts look at the evidence

<p>It’s usually around this time of year you hear people complain about their phones slowing down. Apple and Google release new versions of their operating systems (OS) and suddenly there’s a slew of people <a href="https://www.bbc.com/news/technology-51413724">claiming their old devices have started to lag</a> – conveniently just before Christmas. </p> <p>But do manufacturers really slow down our phones on purpose to nudge us towards shiny new ones, <a href="https://www.npr.org/2020/11/18/936268845/apple-agrees-to-pay-113-million-to-settle-batterygate-case-over-iphone-slowdowns">as has been claimed</a>? </p> <p>The answer to this, as usual, is complicated. Let’s take a look at the evidence.</p> <h2>The ol’ operating system shuffle</h2> <p>Every year, usually around <a href="https://infonewt.com/apple-release-patterns">May and June</a>, tech companies announce their new OS updates. The main news surrounding the releases is often <a href="https://www.macstories.net/stories/ios-and-ipados-15-the-macstories-overview/">new system features</a>such as <a href="https://support.apple.com/en-au/HT204380">Facetime</a> enhancements, improvements to <a href="https://www.theverge.com/2021/6/7/22522993/apple-siri-on-device-speech-recognition-no-internet-wwdc">voice assistants</a>, or a <a href="https://www.wired.com/2013/06/ios7-redesign/">fancier system design</a>.</p> <p>But did you know these features are optimised for the new hardware traditionally released during the summer, and the chips that come with it? </p> <p>As such, system updates have to be programmed to work towards two goals. The first is to support the new hardware and chip, which deliver the newest features. </p> <p>The second is to continue to work with existing hardware that won’t support the new features. And this means coding the OS so it’s not reliant on the new features having to work.</p> <p>This challenge exists for desktop OSs as well, as evidenced by the recent removal of old systems <a href="https://www.theverge.com/2021/6/29/22555371/microsoft-windows-11-cpu-support-hardware-requirements-tpm-response">from the Windows 11 compatibility list</a>. Microsoft decided coding around new features was an insurmountable challenge in some instances. </p> <h2>Hardships with hardware</h2> <p>So your old smartphone won’t support new features – fair enough. But why does it feel like the new OS update is making existing features slower? To understand this, you need to first understand some of the mechanics of chip design.</p> <p>Apple used to use other manufacturers’ chips for its devices, but for the past few years has made its own custom silicon. This is referred to as a “<a href="https://anysilicon.com/what-is-a-system-on-chip-soc/">system on a chip (SoC)</a>, as the entire system exists on a single chip designed and manufactured by Apple.</p> <p>But even if manufacturers design their own chips, it can be hard to predict what consumers will want in the future, and thus which upgrades will come with future iterations of a device. </p> <p>Manufacturers have to write OS updates to suit the latest hardware, so consumers who purchase it can take advantage of the latest features. In doing so, they must work around the fact that older hardware doesn’t have the same capacity. </p> <p>These workarounds mean older devices will run more slowly with the new OS installed, even for tasks the system had done for years. The latest OS is not written to make your old device slower, but because it’s written for the latest device, it can’t help but run more slowly on old hardware. </p> <p>Examples of this abound in the industry, <a href="https://arstechnica.com/gadgets/2020/09/ios-14-on-the-iphone-6s-and-se-performance-is-fine-other-stuff-is-not/">with many articles written</a> about a newly released OS version running slow on older devices until the manufacturer optimises it (if they ever do).</p> <p>You might be wondering: if a new OS will slow down old phones, why install the update at all? </p> <p>Well, it’s because people don’t like being told to stick with old features. Apple <a href="https://9to5mac.com/2021/06/07/apple-will-let-users-stay-on-ios-14-and-receive-security-updates-even-after-ios-15-is-released/">recently allowed</a> users of its latest devices to keep the old system, but this is unusual. There is usually a <a href="https://www.popsci.com/update-every-gadget/">push for users to install new OS versions</a>.</p> <h2>It’s all business</h2> <p>The truth is device manufacturers are in the business to make money. And this means being able to sell new devices. </p> <p>While there is often an <a href="https://theconversation.com/upgrade-rage-why-you-may-have-to-buy-a-new-device-whether-you-want-to-or-not-153105">implied expectation</a> from consumers that manufacturers will commit to maintaining old products, at the same time they need to write updates that will work for their latest hardware. </p> <p>Meanwhile, tech companies aren’t doing enough to educate users on how to adjust their settings to get the best out of their phones, or <a href="https://www.wired.com/story/remove-bloatware-phone/">how to manage software bloat</a> which might contribute to a phone slowing down. </p> <p>Compounding this are other factors such as network connection issues, like when the 3G mobile network was stopped.</p> <h2>Burden of proof</h2> <p>There’s something else to consider, too. If an OS update was designed to intentionally slow down a phone over time, this would be very difficult to prove. </p> <p>The system codes are "closed source”, so experts can’t look into them. The best we can do is run timers on different processes and see if they are slowing down over time.</p> <p>But even if they are, is it because of a system update that can’t be supported by old hardware, or is it malicious conduct from the manufacturer? Could the code be written to force the device to sleep for half a second, every ten seconds, with a sleep command? </p> <p>It’s hard to say for sure, although our personal opinion is this is highly unlikely.</p> <h2>Choose not to play</h2> <p>Ultimately, the issue comes down to how device manufacturers sell their products. </p> <p>The best option for their bottom line is to deliver OS updates and features that work with the latest hardware, even if this leaves old devices behind. The evidence suggests manufacturers are not intentionally slowing phones down, but are prioritising the latest release so you’ll buy it. </p> <p>In the meantime, if your slow device is getting you down, the best option is to resist the urge to upgrade. You might get prompts directing you to install the latest OS version (and the frequency of these will depend on the company) but you can ignore them. </p> <p>There may be auto-updates which you can’t avoid, but in most cases these are for security purposes and don’t include major changes or new features. It’s only once these security updates stop coming that you should upgrade.</p> <p>Until then, a phone running on its original OS should, in theory, run well for a long time.</p> <p><em>Image credits: Getty Images</em></p> <p><em>This article originally appeared on <a href="https://theconversation.com/are-our-phones-really-designed-to-slow-down-over-time-experts-look-at-the-evidence-170962" target="_blank" rel="noopener">The Conversation</a>. </em></p>

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Researchers puzzled by results of anti-inflammatory medications for osteoarthritis

<p>Researchers in the US are calling for a re-evaluation of the way some well known painkillers are prescribed after research showed they may actually lead to a worsening of inflammation over time in osteoarthritis-affected knee joints.</p> <p>NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) such as ibuprofen and naproxen are designed to reduce inflammation for the estimated 2.2 million Australians suffering from the sometimes debilitating effects of osteoarthritis.</p> <p>Osteoarthritis is a degenerative condition affecting joints in the body – most commonly hips, knees, ankles, spine and hands – which results from the degradation of cartilage on the ends of bones within the joints. As the cartilage wears away, the bones rub together resulting in swelling, pain and restricted movement.</p> <p>To combat this pain and swelling, NSAIDs are commonly prescribed, however the long-term impact of this type of medication is unclear, including its effect on the progression of the condition.</p> <p>“To date, no curative therapy has been approved to cure or reduce the progression of knee osteoarthritis,” said the study’s lead author, Johanna Luitjens, from the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. “NSAIDs are frequently used to treat pain, but it is still an open discussion of how NSAID use influences outcomes for osteoarthritis patients.</p> <p>Surprisingly the report says: “…the impact of NSAIDs on synovitis, or the inflammation of the membrane lining the joint, has never been analysed using MRI-based structural biomarkers.”</p> <p>The study compared 793 participants with moderate to severe osteoarthritis of the knee who did not use NSAIDs, with 277 patients who received sustained treatment with NSAIDs for more than a year. Each patient underwent Magnetic Resonance Imaging (MRI) scans of the joint, which were then repeated after four years.</p> <p>The researchers were able to assess the images for indications of inflammation and arthritis progression including cartilage thickness and composition.</p> <p>The data showed the group using NSAIDs, had worse joint inflammation and cartilage quality than those not using NSAIDs, at the time of the initial MRI scan. And the follow-up imaging showed the conditions had worsened for the NSAID group.</p> <p>“In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint,” said Luitjens.</p> <p>According to Luitjens, the common practice of prescribing NSAIDs for osteoarthritis should be revisited as there doesn’t appear to be any evidence they have a positive impact on joint inflammation nor do they slow or prevent synovitis or degenerative changes in the joint.</p> <p>There is also a possibility that NSAIDs simply mask the pain. Despite adjusting the study’s model for individual levels of patient physical activity, “patients who have synovitis and are taking pain-relieving medications may be physically more active due to pain relief, which could potentially lead to worsening of synovitis,” said Luitjens.</p> <p>Luitjens hopes future studies will better characterise NSAIDs and their impact on osteoarthritic inflammation. With one in three people over the age of 75 in Australia suffering from osteoarthritis and an estimated one in 10 women and one in 16 men set to develop it in the future, unlocking treatment options for this crippling condition is an imperative.</p> <p><strong>This article originally appeared on <a href="https://cosmosmagazine.com/science/osteoarthritis-puzzled-antiinflammatory/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Clare Kenyon.</strong></p> <p><em>Image: Shutterstock</em></p>

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Evidence that human evolution driven by major environmental pressures discovered

<p>The genes of ancient humans might have changed substantially due to environmental pressures and change, say an international team of researchers.</p> <p>A widely held belief related to human evolution is that our ancient ancestors’ ability to fashion tools, shelter, and use advanced communication skills may have helped to shield them from large environmental impacts such as changing climate, disease and exposure to other events affecting mortality.</p> <p>But research led out of Australian Centre for Ancient DNA at the University of Adelaide suggests that beneficial genes may have played a more important role in preserving our ancestors.</p> <p>Until now, the sudden increase in frequency of these genes in human groups was masked by the exchange of DNA between people during reproduction.</p> <p>Now, analyses of more than one thousand ancient genomes dating as far back as 45,000 years ago have found historic signals showing genetic adaptation was more common than previously thought.</p> <p>The study of evolutionary events, says the study’s co-lead author Dr Yassine Souilmi, has increased substantially in recent years, as these are the points where human genetics take historic turns.</p> <p>“Evolutionary events [are] exactly what shape our genetic diversity today,” Souilmi tells Cosmos.</p> <p>“That’s what makes us vulnerable to certain diseases [and] resistant to others.</p> <p>“Having a good understanding of evolution, we can have a better understanding of who we are.”</p> <p>Previous research by the Centre has uncovered a range of evolutionary trends, from historic climate change causing the demise of ancestral lions and bears, to the first interactions between humans and coronaviruses 20,000 years ago.</p> <p>And the broader field of research into ancient DNA has shed light on important moments in human history. Only recently did analyses of ancient genes uncover locations on the human genome associated with surviving Yersinia pestis – the bacterium that causes the bubonic plague.</p> <h2>Single events probably triggered selection</h2> <p>This study, published in Nature Ecology and Evolution, has similarly found environmental events might have been more influential on evolution among Eurasian groups.</p> <p>Such events might lead to a point of natural selection. Take, for instance, the emergence of a pathogen. If such a disease could kill people, those who managed to survive and continue reproducing would pass down favourable traits to subsequent generations.</p> <p>“Natural selection acts in two different mechanisms,” says Souilmi.</p> <p>“It only cares about whether you’re procreating successfully… when it acts, it’s either killing a lot of people, [preventing] some people from reproducing successfully, or some people are just not finding mates because they have some sort of ailment that’s not allowing them to mate successfully, or might make them undesirable.</p> <p>“What we’re finding is that the signal of natural selection we detected in this [research] was likely a single event, because the signal is clustered in time in a very early migration out of Africa.</p> <p>“Not all of the [events] we detected occurred at the same time, but the bulk of them did.”</p> <h2>A mirror to the present</h2> <p>This ‘agnostic’ study did not seek to identify the external pressures leading to the selection events indicated in these ancient genes, but future research by the team will seek to uncover that information.</p> <p>Studies like this, or those into specific pressures like the influence of the Black Death or coronaviruses on humans, show the impact of environmental change on our genetics.</p> <p>Souilmi says this is both insightful and cautionary, as environmental change in the present could be studied by humans in the future.</p> <p>He speculates that changes in the Earth’s climate, or the emergence of new pathogens, likely imposed selection pressures on ancient groups, whether through forcing shortages or changes to food supply or imposing physiological stressors.</p> <p>“Very likely, it’s the environment, the temperature, the weather patterns, that would have somewhat impacted the dietary regime of our ancestors out of Africa, and pathogens would have driven this [genetic] adaptation, which has shaped our genetic diversity now,” Souilmi says.</p> <p>“The direct lesson, socially, now, is that if we’re ever faced with events that are similar to that, we are not as immune to extreme episodes of adaptation where a lot of people might die, or be unable to reproduce.</p> <p>“Unless we do something to counteract the environmental changes, or viruses, bacterial or other pandemics, it could be a bad thing.”</p> <p><strong>This article originally appeared on <a href="https://cosmosmagazine.com/science/human-evolution-driven-by-environment/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Matthew Agius.</strong></p> <p><em>Image: Shutterstock</em></p>

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Olivia Newton-John's selfless final wish

<p>Olivia Newton-John's final wishes have been revealed by her husband, as the star continued to lobby for fair and equal medical treatment until her final days. </p> <p>Olivia's husband, John Easterling, shared that Olivia wanted other patients to have the same access to alternative treatments that she felt "privileged" to be able to use. </p> <p>Speaking with the Herald Sun, John said, "Her dream with the Olivia Newton-John Wellness Centre was to have Australians going through cancer have access to the similar types of treatments."</p> <p>According to John, treatments such as medicinal cannabis "undoubtedly extended Olivia's life and gave her quality of life.</p> <p>For much of her life, Olivia lobbied for politicians to change regulations around medicinal cannabis to make it available to patients at Melbourne's ONJ Cancer Wellness and Research Centre.</p> <p>Olivia publicly advocated for alternative treatments even in her final hours and John noted his late wife didn't need "toxic chemicals or addictive painkillers" to manage her terminal illness.</p> <p>John also revealed to The Herald Sun that Olivia was "pain free" and "cheerful and joyful" in her final days.</p> <p>After her first breast cancer diagnosis in 1992, Olivia tried herbal formulas, meditation and "focused on a vision of complete wellness," which inspired Olivia to establish the institution after wanting to "help others going through the same journey".</p> <p>Olivia died after losing her decades-long battle with breast cancer in August. </p> <p><em>Image credits: Instagram </em></p>

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